If I didn't already have more .22 rimfire rifles than I know what to do with, I would probably build one of the lowers into a nice .22 rimfire.No problem. Build a dedicated .22 rim fire. Now you won’t have to start reloading a new caliber! Go with a CMMG conversion kit and barrel. Buy the better mag adapter to use S&W .22 magazines.
I'm still hot on the .17 Win Super Mag. If I can find a barrel and a bolt to match, one of the lowers is definately getting that treatment.