It’s not the first reload you need to worry about. As long as you’re not a complete dolt and follow directions, reloading is usually safe. However, after about the 10th reloading, subtle errors will begin to tell. For example, if your knocking your shoulders back too much, you’ll start to get case head separation. That’s pretty exciting when it happens. I’m pretty diligent about inspecting cases now.
You do know there's more to reloading then just making the gun go BANG? Each and every gun is slightly different just like each and every powder is different (sometimes from lot # to lot# too) Try loading small amounts of rounds like 10-12 with different bullet weights and powders and charges, keep track and sooner or later you'll start to notice that gun A likes a heavy bullet with xx grains of such and such powder. Or you can just find something works and makes your gun go BANG.